Protein function

a practical approach
  • 306 Pages
  • 3.86 MB
  • 5975 Downloads
  • English

IRL Press , Oxford, New York
Proteins -- Analysis., Proteins -- Structure-activity relationships., Proteins -- Affinity labeling., Biochemistry -- Technique., Proteins -- physio
Statementedited by T.E. Creighton.
SeriesThe Practical approach series
ContributionsCreighton, Thomas E., 1940-
Classifications
LC ClassificationsQP551 .P69583 1989
The Physical Object
Paginationxx, 306 p. :
ID Numbers
Open LibraryOL2053992M
ISBN 100199630070, 0199630062
LC Control Number88031963

The region of a protein that associates with a ligand, known as the ligand’s binding site, usually consists of a cavity in the protein surface formed by a particular arrangement of amino acids.

These amino acids can belong to different portions of the polypeptide chain that are brought together when the protein folds (Figure ).Separate regions of the protein surface generally.

Protein Structure and Function is a comprehensive introduction to the study of proteins and their importance to modern biochemistry. Each chapter addresses the structure and function of proteins with a definitive theme designed to enhance student understanding.

Description Protein function PDF

Opening with a brief historical overview of the subject the book moves on to discuss Cited by: Proteins are the most versatile macromolecules in living systems and serve crucial functions in essentially all biological processes.

They function as catalysts, they transport and store other molecules such as oxygen, they provide mechanical support and immune protection, they generate movement, they transmit nerve impulses, and they control growth and by: function, the amino acid sequence alone does not guarantee that the polypeptide will be biologically active.

The polypeptide must fold into a specific three-dimensional structure before it can perform its biological function(s). Once folded into its biologically active form, the polypeptide is termed a protein.

Proteins come in various sizesFile Size: 2MB. This book is about protein structural bioinformatics and how it can help understand and predict protein function. It covers structure-based methods that can assign and explain protein function based on overall folds, characteristics of protein surfaces, occurrence of small 3D motifs, protein-protein interactions and on dynamic : Paperback.

Published by New Science Press and distributed in the U.S. and Canada by Oxford University Press This text introduces general principles of protein structure, folding, and function, then goes beyond these basics to tackle the conceptual basis of inferring structure and function from genomic sequence.

It is the first book in a series, Primers in Biology, employing a modular 5/5(1). Protein function is just as much about where a protein is located as it is about the shape of that protein.

Proteins that are synthesized on the surface of the RER travel through a series of membrane compartments known as the endomembrane system, which functions to modify and sort proteins to their correct destinations inside and outside the cell.

A single protein molecule may contain one or more of these protein structure levels and the structure and intricacy of Protein function book protein determine its function. Collagen, for example, has a super-coiled helical shape that is long, stringy, strong, and rope-like—collagen is great for providing : Regina Bailey.

The key to protein function, however, is the wide range of motions exhibited by the molecules, from local vibrational fluctuations to larger global movements significantly altering the Author: Pascal Gagneux.

The sequence of amino acids determines each protein's unique 3-dimensional structure and its specific function such as catalysis of biochemical reactions, mechanical support. The highly successful original volume, Protein Function: A Practical Approach, has been completely updated and extended to produce this second edition.

Nevertheless, the goal remains the same: the present experimental procedures for analysing protein function that are applicable to many proteins and that can be performed in a typical laboratory. Published by New Science Press, this text introduces general principles of protein structure, folding, and function, then goes beyond these basics to tackle the conceptual basis of inferring structure and function from genomic sequence/5(16).

Because 3D protein structure is generally more well conserved than protein sequence, structural similarity is a good indicator of similar function in two or more proteins. Many programs have been developed to screen an unknown protein structure against the Protein Data Bank and report similar structures (for example, FATCAT (Flexible structure AlignmenT by Chaining AFPs.

Book Description. Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the structure, function, and motion of proteins for students, faculty, and researchers at all levels.

The book covers proteins and enzymes across a wide range of contexts and applications, including medical disorders, drugs, toxins, chemical warfare, and animal behavior. Protein–protein interactions also regulate enzymatic activity, control progression through the cell cycle, and allow the assembly of large protein complexes that carry out many closely related reactions with a common biological function.

Proteins can also bind to, or even be integrated into, cell membranes.

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Introducing a new cutting edge book on protein structure and function that is an ideal introduction for students and a must for all reading lists. Protein Structure and Function considers the key concepts of protein structure and function and the relationship between sequence, structure and function with clear, concise explanations and full colour illustrations/5(3).

The structure of protein sets the foundation for its interaction with other molecules in the body and, therefore, determines its function. Author: Yolanda Smith, Protein Function book.

Read reviews from world’s largest community for readers.5/5(1). This volume presents established bioinformatics tools and databases for function prediction of proteins.

Details Protein function EPUB

Reflecting the diversity of this active field in bioinformatics, the chapters in this book discuss a variety of tools and resources such as sequence- structure- systems- and interaction-based function prediction methods, tools for functional analysis of metagenomics data.

This book is an introductory text for researchers in protein biochemistry, molecular biology, cell biology, chemistry, biophysics and biomedical research. The book also makes an ideal textbook for graduate and advanced undergraduate courses in protein structure and function, and a supplementary text for related courses.

About the Author. Milk is made of two proteins, casein and whey. Whey protein can be separated from the casein in milk or formed as a by-product of cheese : Joseph Nordqvist. Protein Structure and Function provides a critical survey of our current understanding protein structure and function in the age of genomics.

Moving from sequence to structure, and structure to function, the book also explores the link between sequence and function in a series of case studies in structural and functional genomics.

Protein Functional Analysis (PFA) tools are used to assign biological or biochemical roles to proteins. Protein Functional Analysis using the InterProScan program. Launch InterProScan. PfamScan is used to search a FASTA sequence against a library of Pfam HMM. Launch PfamScan. phmmer is used to search one or more sequences against a sequence.

The other major requirement for protein synthesis is the translator molecules that physically “read” the mRNA codons. Transfer RNA (tRNA) is a type of RNA that ferries the appropriate corresponding amino acids to the ribosome, and attaches each new amino acid to the last, building the polypeptide chain one-by-one.

The book has five chapters. The first is an introduction to the principles of protein structure and folding, with emphasis on proteins' biophysical properties. Chapter 3 covers the regulation of protein function, containing concise descriptions of all the regulatory mechanisms that operate on proteins, from pH to phosphorylation, with Brand: Gregory A.

Petsko. PROTEIN FOLDING AND STABILITY A. Forces That Stabilize Protein Structure B. Protein Denaturation and Renaturation C. Protein Folding Pathways D. Protein Dynamics The atomic structure of myoglobin, an oxygen binding protein, is drawn here as a stick model.

The overall conformation of a protein such as myoglobin is a function of its amino File Size: KB. Protein - Protein - Cofactors: Although some enzymes consist only of protein, many are complex proteins; i.e., they have a protein component and a so-called cofactor.

A complete enzyme is called a holoenzyme; if the cofactor is removed, the protein, no longer enzymatically active, is called the apoenzyme. A cofactor may be a metal—such as iron, copper, or magnesium—a.

A protein molecule is very large compared with molecules of sugar or salt and consists of many amino acids joined together to form long chains, much as beads are arranged on a string.

There are about 20 different amino acids that occur naturally in proteins. Proteins of similar function have similar amino acid composition and sequence. Although it is not yet. PROTEINS: Structure, Function, and Bioinformatics publishes original reports of significant experimental and analytic research in all areas of protein research: structure, function, computation, genetics, and design.

The journal encourages reports that present new experimental or computational approaches for interpreting and understanding data from. Protein deficiency due to a low intake of protein in the diet is unusual as an isolated condition in the U.S. The – Dietary Guidelines for Americans recommend that between 10 and.

It is the third most abundant protein in muscle cells. The protein is enormous, with folded individual protein domains spread across exons (largest known number), with the largest known exon (17, base pairs long), and it is the largest protein known (27, to 33, amino acids, depending on splicing).

Unstructured sequences.The former can learn the basic concepts and techniques underlying the automated prediction of protein function from various types of data, and develop these ideas for their research.

After reading this book (or a portion of it), experimental biologists will be better able to identify the most relevant type of data and the most useful prediction.With bang up-to-date texts from world specialists, and ample hyperlinks to publicly obtainable belongings, this book will in all probability be invaluable to anyone who analysis proteins and the endlessly fascinating relationship between their development and efficiency.

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